What is the role of cohesin in the cell during meiosis?

Cohesin plays a crucial role during meiosis by holding sister chromatids together, which is essential for proper chromosome segregation. During the process of meiosis, homologous chromosomes pair up and undergo genetic recombination, resulting in the formation of sister chromatids. Cohesin forms a proteinaceous ring that encircles these sister chromatids, ensuring that they remain attached to one another.

This attachment is vital, particularly during the first meiotic division (meiosis I). As homologous chromosomes align and then separate into different daughter cells, the cohesin complex must maintain the connection between sister chromatids until anaphase II, where they are finally separated. Therefore, the stability provided by cohesin is critical for the accurate distribution of genetic material and the prevention of nondisjunction, which could lead to aneuploidy.

Thus, the role of cohesin in holding chromatids together is foundational for the integrity of the meiotic process, facilitating the proper execution of chromosomal dynamics required for successful gamete formation.