What indicates an area of DNA with more DNase I activity?

The correct choice highlights the relationship between DNA's physical structure and its interaction with histones. Areas of DNA that have less attraction to histones are typically more accessible and less tightly compacted. This reduced interaction can facilitate the binding of DNase I, an enzyme that cleaves DNA, indicating a higher activity level.

In actively transcribed regions, DNA is generally less tightly wound because it needs to be accessible for transcription factors and RNA polymerase. Therefore, these areas would show increased DNase I sensitivity due to their open chromatin structure, which is less associated with histones. This underpins why indicating a reduced attraction to histones correlates with increased DNase I activity effectively reflects the state of the DNA in that region.