True or False: Aneuploidy involving sex chromosomes is better tolerated than autosomal aneuploidy.

Aneuploidy refers to the presence of an abnormal number of chromosomes in a cell, specifically an addition or loss of chromosomes. In particular, aneuploidy involving sex chromosomes is generally better tolerated than that involving autosomes due to the mechanisms of dosage compensation and the effects on development and health.

In humans and many other organisms, females have two X chromosomes (XX), while males have one X and one Y chromosome (XY). In cases of aneuploidy involving sex chromosomes, such as Turner syndrome (45,X) or Klinefelter syndrome (47,XXY), individuals can still develop relatively normally, although they may experience certain health issues or developmental delays. This is largely because males with an extra X chromosome and females with a missing X can still survive and exhibit a range of phenotypes, which are often mild compared to the severe consequences of aneuploidy involving autosomes.

In contrast, aneuploidy involving autosomes frequently results in more severe developmental problems and is often associated with fetal loss. For instance, conditions like Down syndrome (trisomy 21) can occur but may also lead to significant health challenges. Thus, while there are variations in the effects based on the specific chromosomes involved