The statement "SFNs inhibit HDACs" is:

The statement "SFNs inhibit HDACs" is true. Sulforaphane (SFN) is a compound found in cruciferous vegetables like broccoli and Brussels sprouts, known for its potential health benefits, particularly in cancer prevention. Research has shown that SFN can inhibit histone deacetylases (HDACs), which are enzymes involved in the modification of histones and the regulation of gene expression.

Inhibiting HDACs leads to an increased acetylation of histones, which can result in a more relaxed chromatin structure and facilitate the transcription of genes that may be silenced or downregulated. This action may contribute to the anti-cancer effects of SFN, as it can promote the expression of tumor suppressor genes and apoptosis-related genes while silencing oncogenes.

Understanding the role of HDACs and the mechanisms by which SFN influences their activity offers valuable insight into the cellular processes that can be targeted for therapeutic interventions, particularly in cancer biology.