If two genes are very far apart on a chromosome, what is likely to happen during crossing over?

When two genes are located very far apart on a chromosome, crossing over, or recombination, is likely to occur frequently between them. This is because the physical distance between the genes increases the probability that the homologous chromosomes will exchange segments during meiosis.

In the context of genetics, when crossing over happens, it can result in new combinations of alleles, leading to recombinant gametes. The further apart two genes are, the more likely it is that a crossover event will take place between them, leading to a higher frequency of recombinant phenotypes. Therefore, when considering the potential outcomes of crossing over between widely spaced genes, it becomes evident that frequent crossover events will lead to a variety of offspring phenotypes, indicative of genetic variation and recombination.

This understanding of crossover frequency is fundamental in genetic mapping, where genes that are closer together tend to be inherited together (linked), while those further apart demonstrate a greater chance of being separated by recombination.