During which phase does Shugoshin degrade, leading to the susceptibility of Cohesin?

Shugoshin is a protein that plays a crucial role in the protection of cohesin complexes during the stages of cell division, particularly in meiosis. During meiosis, shugoshin acts to safeguard cohesin, which holds sister chromatids together and is essential for proper chromosome segregation. The degradation of shugoshin allows for the cohesin to be vulnerable, which is critical for the progression through the phases of meiosis.

After Meiosis I, shugoshin is degraded, which is key for the separation of sister chromatids during Anaphase II. The degradation leads to the dissolving of cohesin complexes, allowing sister chromatids to finally be separated when the cell progresses into Anaphase II. This step is essential because without the removal of shugoshin and the subsequent degradation of cohesin, sister chromatids could remain attached, resulting in improper chromosomal distribution.

This understanding situates the correct answer in the context of the phases of meiosis and emphasizes the timing of shugoshin degradation as pivotal for the proper functioning and success of the meiotic process.